A 2018 study in the Journal of Food and Nutrition Research has found that taking LactoSpore® Bacillus coagulans (an ingredient in Nutrafruit’s Queen Garnet Probiotic & Prebiotic) daily significantly reduces clinical symptoms of depression. The probiotic was also found to help sleeplessness and decrease signs of inflammation.

Participants were instructed to take either LactoSpore® or a placebo every morning for 90 days.

Researchers used questionnaires/scales to determine the effectiveness of the probiotic.

All primary measures of effectiveness for the LactoSpore® group were statistically significant on day 60 and this was maintained until the study ended. Measures included the positive changes in:

  • Hamilton Rating Scale for Depression (measures depressed mood, feelings of guilt, suicide, insomnia, anxiety, agitation)
  • Montgomery–Asberg Depression Rating Scale (measures inability to feel, pessimistic thoughts, suicidal thoughts, reduced appetite, reduced sleep, tension, sadness)
  • Sleep quality and depressive symptom severity using 11-item Centre for Epidemiological Stud­ies–Depression Scale (measures irritation, concentration level, depressed feelings, exhaustion, hopefulness, fearfulness, sleep, happiness, loneliness)

The following secondary efficacy parameters were also found to be statistically significant for the LactoSpore®  group: 

  • Clinical Global Impression-Improvement (scale from very much improved to very much worse) and Severity Rating Scales (scale from normal to severely ill)
  • Modified Epworth Sleepiness Scale (measures likelihood of dozing in specific situations)

Researchers also analysed serum myeloperoxidase, an inflammatory biomarker[1], before and after the trial:

  • Significantly reduced in the LactoSpore® group but not placebo group. Inflammation is the culprit behind a multitude of health issues such as diabetes, Alzheimer’s, arthritis, heart disease and IBD.

[1] A biomarker is a measurable indicator of a biological process (e.g. there are indicators of inflammation that can be observed in blood tests)